Methyl p-toluenesulfonate → HCID 73855118, compound

Participants

Reaction Steps

In a manner similar to Example 156, 5-(2-methoxyethoxy)-2-(methylthio)benzothiazole was alkylated with methyl p-toluenesulfonate and then condensed with intermediate N-[4-ethylamino-3-(3-furan-2-ylmethyl-4-oxothiazolidin-2-ylideneamino)phenyl]-2-methoxyacetamide. 1H-NMR (CDCl3): δ 8.09 (1H, s), 7.28–7.38 (3H, m), 7.15 (1H, dd), 6.76 (1H, dd), 6.64 (1H, d), 6.44 (1H, d), 6.33 (1H, m), 5.16 (2H, s), 4.14 (2H, m), 4.01 (2H, s), 3.77 (2H, m), 3.72 (3H, s), 3.51 (3H, s), 3.44 (3H, s), 3.15 (2H, q), 1.23 (3H, t); MS(ESI): 624(MH+).

Provenance & Evidence