4-Ethylamino-3-(4-oxo-3-pyridin-3-ylmethylthiazolidin-2-ylideneamino)benzonitrile → 4-ethylamino-3-[5-(3-methyl-4,5,6,7-tetrahydro-3H-benzothiazol-2-ylidene)-4-oxo-3-pyridin-3-ylmethylthiazolidin-2-ylideneamino]benzonitrile

HRID 1242020Notes

Reaction equation

HRID 1242020 reaction equation
C1(C)C=CC(S([O-])(=O)=O)=CC=1.[CH3:12][N+:13]1[C:17]2[CH2:18][CH2:19][CH2:20][CH2:21][C:16]=2[S:15][C:14]=1SC.[CH2:24]([NH:26][C:27]1[CH:34]=[CH:33][C:30]([C:31]#[N:32])=[CH:29][C:28]=1[N:35]=[C:36]1[N:40]([CH2:41][C:42]2[CH:43]=[N:44][CH:45]=[CH:46][CH:47]=2)[C:39](=[O:48])[CH2:38][S:37]1)[CH3:25]>>[CH2:24]([NH:26][C:27]1[CH:34]=[CH:33][C:30]([C:31]#[N:32])=[CH:29][C:28]=1[N:35]=[C:36]1[N:40]([CH2:41][C:42]2[CH:43]=[N:44][CH:45]=[CH:46][CH:47]=2)[C:39](=[O:48])[C:38](=[C:14]2[N:13]([CH3:12])[C:17]3[CH2:18][CH2:19][CH2:20][CH2:21][C:16]=3[S:15]2)[S:37]1)[CH3:25]

Participants

3

Reactant 2

HCID 219374444-Ethylamino-3-(4-oxo-3-pyridin-3-ylmethylthiazolidin-2-ylideneamino)benzonitrileHCID 219375263-Methyl-2-methylthio-4,5,6,7-tetrahydrobenzothiazol-3-ium p-toluenesulfonate

Product 1

HCID 723996334-ethylamino-3-[5-(3-methyl-4,5,6,7-tetrahydro-3H-benzothiazol-2-ylidene)-4-oxo-3-pyridin-3-ylmethylthiazolidin-2-ylideneamino]benzonitrile

Procedure

The title compound was prepared in a manner similar to Example 168 by condensing intermediate 3-methyl-2-methylthio-4,5,6,7-tetrahydro-benzothiazol-3-ium p-toluenesulfonate with 4-ethylamino-3-(4-oxo-3-pyridin-3-ylmethylthiazolidin-2-ylideneamino)benzonitrile. MS(ESI): 503 (MH+).

Sources & evidence

ORD record
ord-8407b07b663449099295003c9b560e28
Source dataset
uspto-grants-2006_10
Patent number
US07115640B2

Reaction notes

Loading…