3-Methyl-2-methylthio-4,5,6,7-tetrahydrobenzothiazol-3-ium p-toluenesulfonate → methyl 4-[2-(5-acetyl-2-ethylamino-phenylimino)-5-(3-methyl 4,5,6,7-tetrahydro-3H-benzothiazol-2-ylidene)-4-oxothiazolidin-3-ylmethyl]benzoate
Reaction equation
C1(C)C=CC(S([O-])(=O)=O)=CC=1.[CH3:12][N+:13]1[C:17]2[CH2:18][CH2:19][CH2:20][CH2:21][C:16]=2[S:15][C:14]=1SC.[CH3:24][O:25][C:26](=[O:53])[C:27]1[CH:32]=[CH:31][C:30]([CH2:33][N:34]2[C:38](=[O:39])[CH2:37][S:36][C:35]2=[N:40][C:41]2[CH:46]=[C:45]([C:47](=[O:49])[CH3:48])[CH:44]=[CH:43][C:42]=2[NH:50][CH2:51][CH3:52])=[CH:29][CH:28]=1>>[C:47]([C:45]1[CH:44]=[CH:43][C:42]([NH:50][CH2:51][CH3:52])=[C:41]([N:40]=[C:35]2[N:34]([CH2:33][C:30]3[CH:31]=[CH:32][C:27]([C:26]([O:25][CH3:24])=[O:53])=[CH:28][CH:29]=3)[C:38](=[O:39])[C:37](=[C:14]3[N:13]([CH3:12])[C:17]4[CH2:18][CH2:19][CH2:20][CH2:21][C:16]=4[S:15]3)[S:36]2)[CH:46]=1)(=[O:49])[CH3:48]Participants
3
Reactant 2
Product 1
Procedure
The title compound was prepared in a manner similar to Example 168 by condensing intermediate 3-methyl-2-methylthio-4,5,6,7-tetrahydro-benzothiazol-3-ium p-toluenesulfonate with 4-[2-(5-acetyl-2-ethylaminophenylimino)-4-oxothiazolidin-3-ylmethyl]benzoic acid methyl ester. MS(ESI): 577 (MH+).
Sources & evidence
- ORD record
- ord-702fe6a6add94267b83120812b8edeae
- Source dataset
- uspto-grants-2006_10
- Patent number
- US07115640B2
Reaction notes
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