反应详情

To an ethanol (10 ml) solution of methyl 4-nitro-3-(oxopropyl)benzoate (13.0 g), added is palladium-carbon (5%, 2.6 g) in a nitrogen atmosphere. This is purged with hydrogen, and further stirred at room temperature for 3 hours and then at 60° C. for 19 hours. The solid is removed through filtration, and the filtrate is concentrated. The resulting oily product is crystallized from toluene. The crystal formed is collected and dried to obtain 5-(methoxycarbonyl)-2-methylindole (8.42 g).

1. customThis is purged with hydrogen
2. waitat 60° C. for 19 hours
3. customThe solid is removed through filtration
4. concentrationthe filtrate is concentrated
5. customThe resulting oily product is crystallized from toluene
6. customThe crystal formed
7. customis collected
8. customdried