P-Anisidine → HCID 21937979, compound

HRID 1242172Notes

Reaction equation

HRID 1242172 reaction equation
F[C:2]1[CH:3]=[C:4]([OH:11])[CH:5]=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9].[CH3:12][O:13][C:14]1[CH:19]=[CH:18][C:17]([NH2:20])=[CH:16][CH:15]=1>ClCCl>[CH3:12][O:13][C:14]1[CH:19]=[CH:18][C:17]([NH:20][C:2]2[CH:3]=[C:4]([OH:11])[CH:5]=[CH:6][C:7]=2[N+:8]([O-:10])=[O:9])=[CH:16][CH:15]=1

Participants

4

Reactant 2

HCID 7732P-AnisidineHCID 5209483-Fluoro-4-nitrophenol

Product 1

HCID 21937979HCID 21937979, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
150 °C

Procedure

0.16 g of 3-fluoro-4-nitrophenol and 0.37 g of p-anisidine were mixed and stirred for 1.5 hours at 150° C. After cooling, it was dissolved in dichloromethane, and extracted twice with 1N aqueous hydrochloric acid and once with saturated sodium chloride solution. The organic phase was dried on sodium sulfate and concentrated by evaporation in a vacuum.

Workup

  1. temperatureAfter cooling
  2. extractionextracted twice with 1N aqueous hydrochloric acid and once with saturated sodium chloride solution
  3. customThe organic phase was dried on sodium sulfate
  4. concentrationconcentrated by evaporation in a vacuum

Sources & evidence

ORD record
ord-4c6fdeb3b3ed4a4dac925bdfba509b5b
Source dataset
uspto-grants-2006_10
Patent number
US07115645B2

Reaction notes

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