3,4-Dimethoxyaniline → HCID 21937960, compound

HRID 1242173Notes

Reaction equation

HRID 1242173 reaction equation
F[C:2]1[CH:3]=[C:4]([OH:11])[CH:5]=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9].[CH3:12][O:13][C:14]1[CH:15]=[C:16]([CH:18]=[CH:19][C:20]=1[O:21][CH3:22])[NH2:17]>ClCCl>[CH3:12][O:13][C:14]1[CH:15]=[C:16]([NH:17][C:2]2[CH:3]=[C:4]([OH:11])[CH:5]=[CH:6][C:7]=2[N+:8]([O-:10])=[O:9])[CH:18]=[CH:19][C:20]=1[O:21][CH3:22]

Participants

4

Reactant 2

HCID 227703,4-DimethoxyanilineHCID 5209483-Fluoro-4-nitrophenol

Product 1

HCID 21937960HCID 21937960, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
150 °C

Procedure

3 g of 3-fluoro-4-nitrophenol and 8.8 g of 3,4-dimethoxyaniline were mixed and stirred for 2 hours at 150° C. After cooling, it was dissolved in dichloromethane and extracted twice with 1N aqueous hydrochloric acid. The aqueous phase was extracted twice with chloroform, and the combined chloroform extracts were dried on sodium sulfate and concentrated by evaporation in a vacuum.

Workup

  1. temperatureAfter cooling
  2. extractionextracted twice with 1N aqueous hydrochloric acid
  3. extractionThe aqueous phase was extracted twice with chloroform
  4. dry with materialthe combined chloroform extracts were dried on sodium sulfate
  5. concentrationconcentrated by evaporation in a vacuum

Sources & evidence

ORD record
ord-7466382437bb46b9855d801331306edd
Source dataset
uspto-grants-2006_10
Patent number
US07115645B2

Reaction notes

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