Sodium Hydroxide → 5-Fluoro-2,4-dinitrophenol

HRID 1242182Notes

Reaction equation

HRID 1242182 reaction equation
[F:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][C:5]([N+:11]([O-:13])=[O:12])=[C:4](F)[CH:3]=1.[OH-:15].[Na+]>O>[F:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][C:5]([N+:11]([O-:13])=[O:12])=[C:4]([OH:15])[CH:3]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 675981,5-Difluoro-2,4-dinitrobenzene

Product 1

HCID 150838855-Fluoro-2,4-dinitrophenol

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

0.41 g of 1,3-difluoro-4,6-dinitrobenzene was dissolved in 8 ml of 0.5 N aqueous sodium hydroxide solution and refluxed for 2 hours. After cooling, it was diluted with water and extracted three times with diethyl ether. The aqueous phase was made acidic by adding 1N hydrochloric acid and extracted with diethyl ether. The organic phase was dried on sodium sulfate and concentrated by evaporation in a vacuum.

Workup

  1. temperaturerefluxed for 2 hours
  2. temperatureAfter cooling
  3. extractionextracted three times with diethyl ether
  4. additionby adding 1N hydrochloric acid
  5. extractionextracted with diethyl ether
  6. customThe organic phase was dried on sodium sulfate
  7. concentrationconcentrated by evaporation in a vacuum

Sources & evidence

ORD record
ord-48b5eafb6e3345a3b5a002190c08fae3
Source dataset
uspto-grants-2006_10
Patent number
US07115645B2

Reaction notes

Loading…