HRID1242217

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2777399

4-(Trifluoromethyl)benzenesulfonyl chloride

C7H4ClF3O2S

结构：COC(=O)CCCCCOc1cc2c(cc1N)nc(-c1ccccc1)n2-c1ccc(OC)cc1

HCID67364071

未命名化合物

PRODUCTS

生成物

结构：COC(=O)CCCCCOc1cc2c(cc1NS(=O)(=O)c1ccc(C(F)(F)F)cc1)nc(-c1ccccc1)n2-c1ccc(OC)cc1

HCID10211853

未命名化合物

PROCEDURE

实验过程

6-[(5-Amino-1-(4-methoxyphenyl)-2-phenyl-1H-benzimidazol-6-yl)oxy]hexanoic acid methyl ester was reacted with 4-(trifluoromethyl)benzenesulfonic acid chloride according to general operating instructions 13.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-187f230b8d6d4f18bbff114ebf2c6587
来源数据集: uspto-grants-2006_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07115645B2
来源说明: uspto-grants-2006_10

反应 SMILES

[CH3:1][O:2][C:3](=[O:34])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][O:9][C:10]1[C:11]([NH2:33])=[CH:12][C:13]2[N:17]=[C:16]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[N:15]([C:24]3[CH:29]=[CH:28][C:27]([O:30][CH3:31])=[CH:26][CH:25]=3)[C:14]=2[CH:32]=1.[F:35][C:36]([F:48])([F:47])[C:37]1[CH:42]=[CH:41][C:40]([S:43](Cl)(=[O:45])=[O:44])=[CH:39][CH:38]=1>>[CH3:1][O:2][C:3](=[O:34])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][O:9][C:10]1[C:11]([NH:33][S:43]([C:40]2[CH:39]=[CH:38][C:37]([C:36]([F:35])([F:47])[F:48])=[CH:42][CH:41]=2)(=[O:45])=[O:44])=[CH:12][C:13]2[N:17]=[C:16]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[N:15]([C:24]3[CH:29]=[CH:28][C:27]([O:30][CH3:31])=[CH:26][CH:25]=3)[C:14]=2[CH:32]=1