Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | Methyl 6-Bromohexanoate | HCID 4170292 | — |
| Reactant | HCID 21938057 | HCID 21938057 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 67365975 | HCID 67365975 | — |
Reaction Steps
75 mg of 4-chloro-N-[1-(4-methoxyphenyl)-2-phenyl-1H-benzimidazol-5-yl]benzenesulfonamide was suspended in 0.5 ml of N,N-dimethylformamide, mixed with 6 mg of sodium hydride and stirred for 30 minutes at 20° C. 44 mg of 6-bromohexanoic acid methyl ester was added, allowed to stir for 15 hours, mixed with water, extracted three times with ethyl acetate, the extracts were dried on sodium sulfate, concentrated by evaporation in a vacuum, and the residue was chromatographed on silica gel.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07115645B2 |
|---|
| Source dataset | uspto-grants-2006_10 |
|---|
| ORD ID | ord-e2d4116d2e304045bf39bee67e1be839 |
|---|
| Source note | uspto-grants-2006_10 |
|---|
