p-Toluenesulfonic acid → HCID 85100428, compound

Participants

Reaction Steps

To a mixture of [2-methyl-3-(4-isopropylphenyl)-propionaldehyde] (3.0 g, 15.8 mmol, 1.0 equiv), N-tert-butylhydroxylamine (1.76 g, 19.7 mmol, 1.3 equiv) and toluene (60 ml) was added p-TsOH (50 mg), and the mixture was stirred at rt for 18 h. Removal of the solvent under reduced pressure gave a solid which was purified by column chromatography (EtOAc:hexane 1:1) to give N-tert-butyl-C-[2-(4-isopropylphenyl)-1-methyethyl]nitrone (1.04 g, 25.18%) as a white solid: 1H NMR (CDCl3) δ 7.12 (d, J=1.0, 4H), 6.63 (d, J=7.2 1H), 3.47–3.31 (m, 1H), 2.89–2.80 (m, 2H), 2.71–2.63 (dd, 1H), 1.44 (s, 9H), 1.25 (d, J=6.9, 3H).

Provenance & Evidence