Phenylacetaldehyde → HCID 315883, compound

Participants

Reaction Steps

To a mixture of phenyl-acetaldehyde (1.20 g, 10.00 mmol) and chloroform (50 ml) was added N-tert-butylhydroxylamine (1.07 g, 12.00 mmol) followed by 5 drops of conc. HCl. The mixture was stirred at rt for 18 h. The mixture was concentrated under vacuum to give an oil. The residue was purified by column chromatography (hexane:EtOAc=1:1) followed by EtOAc to give the title compound as a white solid: Yield: 80%, m.p. 143° C.: 1H NMR (CDCl3) δ 7.38 (m, 5H), 6.90 (s, 1H), 4.95 (dd, 2H), 1.25 (s, 9H).

Provenance & Evidence