2-Methyl-6-(3-trifluoromethyl-phenyl)-pyridine-3-carbaldehyde → [2-Methyl-6-(3-trifluoromethyl-phenyl)-pyridin-3-yl]-methanol

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Reaction Steps

0.500 g (1.89 mmol) of the above prepared 2-methyl-6-(3-trifluoromethyl-phenyl)-pyridine-3-carbaldehyde was dissolved in 9.4 ml of abs. THF and treated at −10° C. with 0.94 ml of 3M methyl magnesium chloride solution (in THF). After 30 Min., the reaction mixture was carefully poured onto crashed ice/NH4Cl, extracted twice with AcOEt, washed with water, dried over sodium sulfate, and evaporated to dryness to leave 0.532 g of the title product, pure according to NMR.

Provenance & Evidence