反应详情

To 0.0944 g (0.336 mmol) of the above prepared (example 1H]) [2-(3-methoxy-propyl)-4-methylamino-phenoxy]-acetic acid ethyl ester and 0.100 g (0.305 mmol) of the above prepared [rac]-3-(1-chloro-butyl)-2-methyl-6-(3-trifluoromethyl-phenyl)-pyridine, dissolved in 1.9 ml of abs. DMSO, were added successively 0.0505 g of K2CO3 (0.366 mmol) and 0.0503 g (0.336 mmol) of NaI. The reaction was allowed to proceed for 5 h at 50° C. Pouring onto crashed ice/NH4Cl, twofold extraction with AcOEt, washing with water, drying over sodium sulfate, and evaporation of the solvents, followed by flash chromatography (SiO2, hexane/AcOEt=8/2), afforded 0.082 g of the title compound as light yellow oil.

1. dissolutiondissolved in 1.9 ml of abs
2. additionPouring
3. extractionice/NH4Cl, twofold extraction with AcOEt
4. washwashing with water
5. dry with materialdrying over sodium sulfate, and evaporation of the solvents