Sodium Iodide

8-9.5

ODORLESS

SALINE, SOMEWHAT BITTER TASTE

3.67

3.67 g/cm³

3.667 @25 °C

COLORLESS, CUBIC CRYSTALS

WHITE CRYSTALS OR GRANULES

WHITE POWDER

Soluble

SOLUBILITY (G/100 CC SOLVENT): 184 G IN WATER @ 25 °C; 302 G IN WATER @ 100 °C; 42.57 G IN ALCOHOL @ 25 °C; 39.9 G IN ACETONE @ 25 °C

1 G SOL IN 1 ML GLYCEROL

Solubility in water, g/100ml at 25 °C: 184

Decomposes

1304 °C

1304 °C

1304 °C @760 [mm Hg]

651

651 °C

660 °C

660 °C

1 MM HG @ 767 °C

1 [mm Hg] @767 °C

INDEX OF REFRACTION: 1.7745

Liquid; CBI; Dry Powder; Wet Solid

White odorless deliquescent solid; Turned brown by air; [Merck Index] Colorless to white hygroscopic solid; [ICSC] White odorless crystalline powder; [MSDSonline]

COLOURLESS-TO-WHITE HYGROSCOPIC CRYSTALS OR WHITE POWDER. TURNS BROWN ON EXPOSURE TO AIR.

IT IS MADE SLIGHTLY ALKALINE TO RENDER IT MORE STABLE

This chemical does not meet GHS hazard criteria for 7.9% (39 of 495) of reports.

Danger

H315 (70.9%): Causes skin irritation [Warning Skin corrosion/irritation]；H319 (72.7%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]；H335 (16.8%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]；H372 (42.8%): Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]；H400 (61.8%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]；H411 (10.1%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

P260, P261, P264, P264+P265, P270, P271, P273, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 495 reports by companies from 36 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.；Reported as not meeting GHS hazard criteria per 39 of 495 reports by companies.；There are 35 notifications provided by 456 of 495 reports by companies with hazard statement code(s).；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

Chemical: Sodium iodide (NaI)

Sodium iodide (NaI) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Sodium iodide (NaI) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 05-04-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/5959；Status: Active Update: 12-01-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/5847；Status: Active Update: 18-02-2020 https://echa.europa.eu/registration-dossier/-/registered-dossier/25025

Sodium iodide: Does not have an individual approval but may be used under an appropriate group standard

IMAP assessments - Sodium iodide (NaI): Human health tier I assessment；IMAP assessments - Sodium iodide (NaI): Environment tier I assessment

Not combustible. Gives off irritating or toxic fumes (or gases) in a fire.

PERCHLORIC ACID IGNITES IN CONTACT WITH SODIUM IODIDE.

A skin, eye, and respiratory tract irritant; If ingested: the substance may have effects on the thyroid and may cause systemic sensitization. Symptoms of systemic sensitization may include airway obstruction and various skin reactions or even anaphylactic shock. Exposure during pregnancy may affect the thyroid function of the newborn. [ICSC] An irritant; [MSDSonline] See Iodine for the TLV of Iodides.

Reacts violently with strong oxidants. This produces iodine fumes.

Skin Irrit. 2 (70.9%)；Eye Irrit. 2 (72.7%)；STOT SE 3 (16.8%)；STOT RE 1 (42.8%)；Aquatic Acute 1 (61.8%)；Aquatic Chronic 2 (10.1%)

(ME) MAINE 340 ug/l /Iodide ion/

In case of fire in the surroundings, use appropriate extinguishing media.

Fresh air, rest.

Remove contaminated clothes. Rinse skin with plenty of water or shower.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Give one or two glasses of water to drink. Refer for medical attention .

Separated from strong oxidants and food and feedstuffs. Dry. Well closed.

KEEP WELL CLOSED & PROTECTED FROM LIGHT.

Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Sweep spilled substance into covered containers.

Wear safety goggles or eye protection in combination with breathing protection if powder.

A harmful concentration of airborne particles can be reached quickly , especially if powdered.

Protective gloves.

PREVENT DISPERSION OF DUST! AVOID EXPOSURE OF (PREGNANT) WOMEN!

Do not eat, drink, or smoke during work.

Use ventilation (not if powder), local exhaust or breathing protection.

0.01 [ppm], inhalable fraction and vapor (iodides)

0.01 ppm as TWA; A4 (not classifiable as a human carcinogen).

...LITHIUM CARBONATE THEORETICALLY COULD INTERACT WITH...SODIUM IODIDE.

The substance can be absorbed into the body by ingestion.

Cough. Sore throat. Headache.

Redness.

Redness.

Diarrhoea. Nausea. Vomiting.

THE OCCASIONAL USE OF IODIDES FOR ASTHMA IN PREGNANCY HAS RESULTED IN FETAL DEATH, SEVERE GOITER & CRETINOID APPEARANCE OF THE NEWBORN. /IODIDE SALTS/

..."IODISM" RESULTS FROM CHRONIC IODIDE OVERDOSES... IODISM IS CHARACTERIZED BY SALIVATION, CORYZA, SNEEZING, CONJUNCTIVITIS, HEADACHE, FEVER, LARYNGITIS, BRONCHITIS, STOMATITIS, PAROTITIS...&...EDEMA OF GLOTTIS...HAS OCCURRED. /IODIDE SALTS/

TEN GRAMS OF SODIUM IODIDE HAVE BEEN GIVEN SLOWLY BY IV ROUTE WITHOUT ILL EFFECTS.

OCCASIONAL INDIVIDUALS SHOW...SENSITIVITY TO IODIDE OR TO ORG PREPN THAT CONTAIN IODINE WHEN...ADMIN IV. ONSET OF AN ACUTE REACTION MAY OCCUR IMMEDIATELY OR SEVERAL HR AFTER ADMIN. ANGIOEDEMA IS OUTSTANDING SYMPTOM, & SWELLING OF LARYNX MAY LEAD TO SUFFOCATION. MULTIPLE CUTANEOUS HEMORRHAGES MAY BE PRESENT. /IODIDE PREPN/

For more Human Toxicity Excerpts (Complete) data for SODIUM IODIDE (10 total), please visit the HSDB record page.

Chemical: Sodium iodide (NaI)

Sodium iodide (NaI) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Sodium iodide (NaI) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 05-04-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/5959；Status: Active Update: 12-01-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/5847；Status: Active Update: 18-02-2020 https://echa.europa.eu/registration-dossier/-/registered-dossier/25025

Sodium iodide: Does not have an individual approval but may be used under an appropriate group standard

(ME) MAINE 340 ug/l /Iodide ion/

When intravenously administered for total parental nutrition, sodium iodide prevents the depletion of endogenous stores of iodine and subsequent deficiency symptoms.

RESPONSE TO IODIDE IN HYPERTHYROIDISM: /IN THYROID GLAND/...VASCULARITY IS REDUCED, GLAND BECOMES MUCH FIRMER & EVEN HARD TO THE TOUCH, CELLS BECOME SMALLER, COLLOID REACCUMULATES IN FOLLICLES, & QUANTITY OF BOUND IODINE INCREASES. /IODIDES/

HIGH CONCN OF IODIDE APPEAR TO INFLUENCE ALL IMPORTANT ASPECTS OF IODINE METABOLISM BY THE THYROID GLAND. CAPACITY OF IODIDE TO LIMIT ITS OWN TRANSPORT... ACUTE INHIBITION OF SYNTHESIS OF IODOTYROSINE & IODOTHYRONINE BY IODIDE IS ALSO WELL KNOWN (THE WOLFF-CHAIKOFF EFFECT)... /IODIDES/

THIS INHIBITION /WOLFF-CHAIKOFF EFFECT/ IS OBSERVED ONLY ABOVE CRITICAL CONCN OF IODIDE, & THE INTRACELLULAR...CONCN OF ANION APPEARS TO BE MAJOR DETERMINANT. WITH TIME THERE IS "ESCAPE" FOR THIS INHIBITION...ASSOCIATED WITH AN ADAPTIVE DECR IN IODIDE TRANSPORT & LOWERED INTRACELLULAR IODIDE CONCN. /IODIDES/

THE MOST IMPORTANT CLINICAL EFFECT OF HIGH IODIDE CONCN IS AN INHIBITION OF THE RELEASE OF THYROID HORMONE. THIS ACTION IS RAPID & EFFICACIOUS IN SEVERE THYROTOXICOSIS. THE EFFECT IS EXERTED DIRECTLY ON THE THYROID GLAND, & IT CAN BE DEMONSTRATED IN EUTHYROID SUBJECT & EXPTL ANIMALS AS WELL AS IN HYPERTHYROID PT. /IODIDES/

IODIDE ANTAGONIZES THE ABILITY OF BOTH THYROTROPIN & CYCLIC AMP TO STIMULATE ENDOCYTOSIS OF COLLOID, PROTEOLYSIS, & HORMONE SECRETION. /REPORTEDLY/... IODIDE ATTENUATES THE EFFECT OF TSH ON CYCLIC AMP IN VIVO & IN ISOLATED TISSUES. /IODIDES/

Iodide salts are readily absorbed in the gastrointestinal tract.

Iodides are expected to be renal excreted.

Iodides are distributed widely throughout extracellular fluid of thyroid gland.

Used in small amounts for wet extraction of silver; Also used in iodized salt and for various applications in human and veterinary medicine; [HSDB] Used in photography, cloud seeding, and as a solvent for iodine; [Hawley]

Photographic Processing [Category: Other]；Metal Extraction and Refining [Category: Industry]

MEDICATION (VET)

MEDICATION

PHOTOGRAPHY; SOLVENT FOR IODINE; ORG CHEMICALS; REAGENT; ARTIFICIAL RAINMAKING; SCINTILLATION (THALLIUM-ACTIVATED FORM)

Small amount used in wet extraction of silver; iodized salt

(1986) No Data

(1986) No Data

2023: 400,000 - <550,000 lb；2022: 400,000 - <550,000 lb；2021: 700,000 - <850,000 lb；2020: 550,000 - <700,000 lb

(1981) 2.96X10+7 g

Cleaning agent；Other

Other；Processing aids not otherwise specified；Photosensitive agent；Intermediate

...FROM IODINE & SODIUM HYDROXIDE, OR BY METATHESIS BETWEEN FERROSOFERRIC IODIDE & SODIUM CARBONATE.

Reaction of sodium carbonate with an acidic iodide solution

USP SODIUM IODIDE IS AT LEAST 99% PURE.

GRADES: TECHNICAL; CP; USP; SINGLE CRYSTALS.

FORMULATIONS (VET): EACH 100 ML CONTAINS SODIUM IODIDE USP 20 G; INERT INGREDIENTS, FORMALDEHYDE (AS PRESERVATIVE) 0.2% WEIGHT/VOLUME, DISTILLED WATER 82.4% WEIGHT/WEIGHT. /SODIUM IODIDE 20%/

/Available in/ high purity, ultra-dry grades & 57% solution grades

NaI-USP XX contains 99-101.5% NaI calc on the anhydrous basis

Cosmetics -> Antimicrobial

All Other Basic Inorganic Chemical Manufacturing；Pharmaceutical and Medicine Manufacturing；Computer and Electronic Product Manufacturing；All Other Chemical Product and Preparation Manufacturing；All Other Basic Organic Chemical Manufacturing

Sodium iodide (NaI): ACTIVE

INCOMPATIBILITIES: SEE POTASSIUM IODIDE. ALKALOIDAL SALTS, CHLORAL HYDRATE, TARTARIC & OTHER ACIDS, CALOMEL, POTASSIUM CHLORATE, METALLIC SALTS. /POTASSIUM IODIDE/