2-Methyl-4-nitrophenol → HCID 45097887, compound

Participants

Reaction Steps

A solution of 15.76 ml (171 mmol) of methyl bromoacetate and 25.0 g (163 mmol) of 2-methyl-4-nitrophenol in 300 ml dry acetonitrile was treated with 61.3 g (188 mmol) Cs2CO3 and stirred at RT for 4 h. The mixture was filtered, washed with acetonitrile and evaporated. The residue was suspended in 700 ml CH2Cl2, filtered and evaporated to give 36.4 g of (2-methyl-4-nitro-phenoxy)-acetic acid methyl ester as yellow crystals.

Provenance & Evidence