5-Chloromethyl-2-(4-chloro-phenyl)-pyridine → HCID 11486303, compound

HRID 1242307Notes

Reaction equation

HRID 1242307 reaction equation
C([O:3][C:4](=[O:16])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([NH:13][CH3:14])=[CH:9][C:8]=1[CH3:15])C.C(OC(=O)COC1C=CC=CC=1CCCOC)C.Cl[CH2:36][C:37]1[CH:38]=[CH:39][C:40]([C:43]2[CH:48]=[CH:47][C:46]([Cl:49])=[CH:45][CH:44]=2)=[N:41][CH:42]=1>>[Cl:49][C:46]1[CH:45]=[CH:44][C:43]([C:40]2[N:41]=[CH:42][C:37]([CH2:36][N:13]([CH3:14])[C:10]3[CH:11]=[CH:12][C:7]([O:6][CH2:5][C:4]([OH:3])=[O:16])=[C:8]([CH3:15])[CH:9]=3)=[CH:38][CH:39]=2)=[CH:48][CH:47]=1

Participants

4

Reactant 3

HCID 219358445-Chloromethyl-2-(4-chloro-phenyl)-pyridineHCID 45097786HCID 45097786, compoundHCID 67072081HCID 67072081, compound

Product 1

HCID 11486303HCID 11486303, compound

Procedure

A] The title compound was prepared in analogy to example 4, but using in step C] (2-methyl-4-methylamino-phenoxy)-acetic acid ethyl ester (prepared in analogy to example 5F])instead of [2-(3-methoxy-propyl)-phenoxy]-acetic acid ethyl ester and 5-chloromethyl-2-(4-chloro-phenyl)-pyridine instead of [rac]-3-(1-chloro-butyl)-2-methyl-6-(3-trifluoromethyl-phenyl)-pyridine, as off-white crystals of mp. 174–76° C.

Sources & evidence

ORD record
ord-3d02bc498a1c4567a70bb92e58ba6675
Source dataset
uspto-grants-2006_10
Patent number
US07115611B2

Reaction notes

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