反应详情

A solution of 357 mg (1.16 mmol) [rac]-1-[4-cyclopropyl-2-(4-trifluoromethyl-phenyl)-pyrimidin-5-yl]-ethanol and 0.09 ml (1.22 mmol) thionylchloride in 4 ml dichloromethane were stirred for 1 h at RT. The reaction mixture was concentrated under reduced pressure to provide 390 mg of pure [rac]-5-(1-chloro-ethyl)-4-cyclopropyl-2-(4-trifluoromethyl-phenyl)-pyrimidine.

1. concentrationThe reaction mixture was concentrated under reduced pressure