Thionyl Chloride → HCID 21935836, compound

HRID 1242336Notes

Reaction equation

HRID 1242336 reaction equation
[F:1][C:2]([F:18])([F:17])[C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:10]=[CH:11][C:12]([CH2:15]O)=[N:13][CH:14]=2)=[CH:5][CH:4]=1.O=S(Cl)[Cl:21]>C(Cl)Cl>[Cl:21][CH2:15][C:12]1[CH:11]=[N:10][C:9]([C:6]2[CH:7]=[CH:8][C:3]([C:2]([F:18])([F:17])[F:1])=[CH:4][CH:5]=2)=[CH:14][N:13]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 21935886HCID 21935886, compound

Product 1

HCID 21935836HCID 21935836, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

0.20 g (0.79 mmol) of the above prepared [5-(4-trifluoromethyl-phenyl)-pyrazin-2-yl]-methanol was dissolved in 8 ml of CH2Cl2 and treated dropwise at 0° C. with 0.11 ml (2 eq.) of SOCl2. The reaction mixture was kept at 0° C. for 1 h, at RT for 18 h and 6 h at 30° C. Evaporation of the solvents and dissolution in ether and heptane with consecutive evaporation afforded 0.21 g of pure title compound as light brown solid.

Workup

  1. customEvaporation of the solvents and dissolution in ether
  2. customheptane with consecutive evaporation

Sources & evidence

ORD record
ord-e9210086a2bb4baba3e96a64cfa93b50
Source dataset
uspto-grants-2006_10
Patent number
US07115611B2

Reaction notes

Loading…