HuagongsheHuagongshe Chemistry Print Report · For research reference only
[Rac]-3-(1-chloro-butyl)-2-methyl-6-(4-trifluoromethyl-phenyl)-pyridine → [Rac]-2-methyl-2-(2-methyl-4-{1-[2-methyl-6-(4-trifluoromethyl-phenyl)-pyridin-3-yl]-butoxy}-phenoxy)-propionic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | [Rac]-3-(1-chloro-butyl)-2-methyl-6-(4-trifluoromethyl-phenyl)-pyridine | HCID 21935692 | — |
| Reactant | 3-Chloromethyl-2-methyl-6-(4-trifluoromethyl-phenyl)-pyridine | HCID 21935751 | — |
| Reactant | [Rac]-2-methyl-2-(2-methyl-4-{1-[2-methyl-6-(4-trifluoromethyl-phenyl)-pyridin-3-yl]-butoxy}-phenoxy)-propionic acid ethyl ester | HCID 67072384 | — |
| Product | [Rac]-2-methyl-2-(2-methyl-4-{1-[2-methyl-6-(4-trifluoromethyl-phenyl)-pyridin-3-yl]-butoxy}-phenoxy)-propionic acid | HCID 21935659 | — |
Reaction Steps
A] The title compound was prepared in analogy to example 34, via [rac]-2-methyl-2-(2-methyl-4-{1-[2-methyl-6-(4-trifluoromethyl-phenyl)-pyridin-3-yl]-butoxy}-phenoxy)-propionic acid ethyl ester, but using in step A] [rac]-3-(1-chloro-butyl)-2-methyl-6-(4-trifluoromethyl-phenyl)-pyridine (example 21B]) instead of 3-chloromethyl-2-methyl-6-(4-trifluoromethyl-phenyl)-pyridine, as colorless foam.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07115611B2 |
| Source dataset | uspto-grants-2006_10 |
| ORD ID | ord-f3f34e2b644e4d11ae138636fe675591 |
| Source note | uspto-grants-2006_10 |