Cesium carbonate → HCID 67072404, compound

Participants

Reaction Steps

To 0.139 g (0.583 mmol) of 2-(4-hydroxy-2-methyl-phenoxy)-2-methyl-propionic acid ethyl ester (described in WO 02/092590) and 0.177 g (0.583 mmol) of 3-chloromethyl-6-(3-fluoro-4-trifluoromethyl-phenyl)-2-methyl-pyridine (example 38C]), dissolved in 3 ml of abs. acetonitrile, was added 0.228 g of Cs2CO3 (0.700 mmol). The reaction mixture was stirred during 3 h at ambient temperature. Pouring onto crashed ice/NH4Cl-solution, twofold extraction with AcOEt, washing with water and brine, drying over magnesium sulfate, and evaporation of the solvents, followed by flash chromatography (SiO2, hexane/AcOEt=88/12) yielded 0.219 g of pure title compound as white solid.

Provenance & Evidence