反应详情

0.300 g (1.059 mmol) of the above prepared [2-methyl-6-(4-trifluoromethoxy-phenyl)-pyridin-3-yl]-methanol was dissolved in 5.3 ml of CH2Cl2 and treated dropwise at 0° C. with 0.15 ml (2 eq.) of SOCl2. The reaction mixture was kept at 0° C. for 5 Min. and at RT for 30 Min. Pouring onto crashed ice/NaHCO3, twofold extraction with AcOEt, washing with water, drying over sodium sulfate and evaporation of the solvents generated 0.315 g of pure title compound as light yellow oil.

1. customwas kept at 0° C. for 5 Min
2. customat RT
3. additionPouring
4. extractionice/NaHCO3, twofold extraction with AcOEt
5. washwashing with water
6. dry with materialdrying over sodium sulfate and evaporation of the solvents