反应详情

0.657 g (2.33 mmol) of the above prepared (example 1L]) 3-dimethylamino-1-(4-trifluoromethyl-phenyl)-propan-1-one hydrochloride and 0.362 g (1.0 eq., not corrected for impurities) of the above synthesised 3-amino-3-cyclopropyl-acrylic acid ethyl ester was dissolved in 7 ml of AcOH and heated to reflux for 3 h. After cooling, the bulk of the solvent was evaporated i. V. Ensuing flash chromatography (SiO2, hexane/AcOEt=93/7) yielded 0.101 g of the title compound as light yellow solid.

1. temperatureheated
2. temperatureto reflux for 3 h
3. temperatureAfter cooling
4. customthe bulk of the solvent was evaporated i