反应详情

0.127 g (0.433 mmol) of the above prepared [2-cyclopropyl-6-(4-trifluoromethyl-phenyl)-pyridin-3-yl]-methanol was dissolved in 2.0 ml of CH2Cl2 and treated at 0° C. with 0.063 ml (2 eq.) of SOCl2. The reaction mixture was kept at 0° C. for 5 Min. and at RT for 60 Min. Pouring onto crashed ice/NaHCO3, twofold extraction with AcOEt, washing with water and brine, drying over magnesium sulfate, and evaporation of the solvents afforded 0.137 g of pure title compound as off-white solid.

1. customwas kept at 0° C. for 5 Min
2. customat RT
3. additionPouring
4. extractionice/NaHCO3, twofold extraction with AcOEt
5. washwashing with water and brine
6. dry with materialdrying over magnesium sulfate, and evaporation of the solvents