3-Chloromethyl-2-methyl-6-(3-trifluoromethyl-phenyl)-pyridine → HCID 21935635, compound

HRID 1242349Notes

Reaction equation

HRID 1242349 reaction equation
C([O:3][C:4](=[O:38])[C:5]([CH3:37])([O:7][C:8]1[CH:13]=[CH:12][C:11]([O:14][CH:15]([C:19]2[C:20]([CH3:35])=[N:21][C:22]([C:25]3[CH:30]=[CH:29][CH:28]=[C:27]([C:31]([F:34])([F:33])[F:32])[CH:26]=3)=[CH:23][CH:24]=2)[CH2:16][CH2:17][CH3:18])=[CH:10][C:9]=1[CH3:36])[CH3:6])C.ClC(C1C(C)=NC(C2C=CC=C(C(F)(F)F)C=2)=CC=1)CCC.ClCC1C(C)=NC(C2C=CC=C(C(F)(F)F)C=2)=CC=1>>[CH3:6][C:5]([O:7][C:8]1[CH:13]=[CH:12][C:11]([O:14][CH:15]([C:19]2[C:20]([CH3:35])=[N:21][C:22]([C:25]3[CH:30]=[CH:29][CH:28]=[C:27]([C:31]([F:33])([F:32])[F:34])[CH:26]=3)=[CH:23][CH:24]=2)[CH2:16][CH2:17][CH3:18])=[CH:10][C:9]=1[CH3:36])([CH3:37])[C:4]([OH:38])=[O:3]

Participants

4

Reactant 3

HCID 219357693-Chloromethyl-2-methyl-6-(3-trifluoromethyl-phenyl)-pyridineHCID 21935942HCID 21935942, compoundHCID 67072149HCID 67072149, compound

Product 1

HCID 21935635HCID 21935635, compound

Procedure

A] The title compound was prepared in analogy to example 8, via [rac]-2-methyl-2-(2-methyl-4-{1-[2-methyl-6-(3-trifluoromethyl-phenyl)-pyridin-3-yl]-butoxy}-phenoxy)-propionic acid ethyl ester, but using instep A] [rac]-3-(1-chloro-butyl)-2-methyl-6-(3-trifluoromethyl-phenyl)-pyridine (example 4B]) instead of 3-chloromethyl-2-methyl-6-(3-trifluoromethyl-phenyl)-pyridine, as white foam.

Sources & evidence

ORD record
ord-3002cee936f64f7b8e271a98f869b9da
Source dataset
uspto-grants-2006_10
Patent number
US07115611B2

Reaction notes

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