Diisobutylaluminum hydride → HCID 21935665, compound

Participants

Reaction Steps

1.250 g (3.717 mmol) of the above prepared 4-cyclopropyl-2-(3-trifluoromethyl-phenyl)-pyrimidine-5-carboxylic acid ethyl ester in 19 ml of abs. THF was cooled down to −15° C. and reacted with 11.2 ml of DIBAL-H-solution (1.0 M in toluene, 3 eq.) for 1/2 h. Careful quenching with ice/HCl dil., twofold extraction with AcOEt, washing with water, drying over sodium sulfate, and evaporation of the solvents left a crude product which was purified by flash chromatography (SiO2, hexane/AcOEt=1/1l) to yield finally 1.096 g of the title compound as white solid of mp. 108–09° C.

Provenance & Evidence