Sodium Hydroxide → HCID 21935669, compound

Participants

Reaction Steps

0.183 g (0.386 mmol) of the above prepared 2-methyl-2-{2-methyl-4-[6-(4-trifluoromethyl-phenyl)-pyridazin-3-ylmethoxy]-phenoxy}-propionic acid ethyl ester was dissolved in 8 ml of THF/EtOH=1/1, treated with 1.16 ml (3 eq.) of 1N NaOH and kept at ambient temperature over night. The reaction mixture was then poured onto crashed ice/AcOEt/HCl dil., the aqueous phase extracted again with AcOEt; the combined organic layers were washed with water, dried over sodium sulfate, and evaporated to dryness to yield, after recrystallisation from hexane/AcOEt, 0.160 g of the title compound as light yellow crystals of mp. 191–192° C.

Provenance & Evidence