反应详情

0.311 g (1.046 mmol) of the above prepared [2-methoxymethyl-6-(4-trifluoromethyl-phenyl)-pyridin-3-yl]-methanol was dissolved in 4 ml of CH2Cl2 and treated at 0C. with 0.15 ml (2 eq.) of SOCl2. The reaction mixture was kept at 0° C. for 5 Min. and at ambient temperature for 60 Min. Pouring onto crashed ice/NaHCO3, twofold extraction with AcOEt, washing with water and brine, drying over magnesium sulfate, and evaporation of the solvents produced 0.330 g of pure title compound as colorless oil.

1. customwas kept at 0° C. for 5 Min
2. customat ambient temperature
3. additionPouring
4. extractionice/NaHCO3, twofold extraction with AcOEt
5. washwashing with water and brine
6. dry with materialdrying over magnesium sulfate, and evaporation of the solvents