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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1242368Generated: October 30, 2026

[Rac]-3-(1-chloro-ethyl)-2-methyl-6-(3-trifluoromethyl-phenyl)-pyridine → [Rac]-(2-methyl-4-{1-[2-methyl-6-(3-trifluoromethyl-phenyl)-pyridin-3-yl]-ethoxy}-phenoxy)-acetic acid

https://huagongshe.com/reaction/1242368

Reaction equation

Participants

RoleNameHCIDCharge
Reactant[Rac]-3-(1-chloro-ethyl)-2-methyl-6-(3-trifluoromethyl-phenyl)-pyridineHCID 21935641—
Reactant[Rac]-3-(1-chloro-butyl)-2-methyl-6-(4-trifluoromethyl-phenyl)-pyridineHCID 21935692—
Reactant[Rac]-(2-methyl-4-{1-[2-methyl-6-(3-trifluoromethyl-phenyl)-pyridin-3-yl]-ethoxy}-phenoxy)-acetic acid ethyl esterHCID 67072315—
Product[Rac]-(2-methyl-4-{1-[2-methyl-6-(3-trifluoromethyl-phenyl)-pyridin-3-yl]-ethoxy}-phenoxy)-acetic acidHCID 21935752—

Reaction Steps

A] The title compound was prepared in analogy to example 46, via [rac]-(2-methyl-4-{1-[2-methyl-6-(3-trifluoromethyl-phenyl)-pyridin-3-yl]-ethoxy}-phenoxy)-acetic acid ethyl ester, but using in step A] [rac]-3-(1-chloro-ethyl)-2-methyl-6-(3-trifluoromethyl-phenyl)-pyridine (example 3C]) instead of [rac]-3-(1-chloro-butyl)-2-methyl-6-(4-trifluoromethyl-phenyl)-pyridine as colorless solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07115611B2
Source datasetuspto-grants-2006_10
ORD IDord-36c347a68ea143a5a4909048cc58c60a
Source noteuspto-grants-2006_10