HRID1242369

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID21935641

未命名化合物

结构：CCCC(Cl)c1ccc(-c2cccc(C(F)(F)F)c2)nc1C

HCID21935942

未命名化合物

结构：CCCC(Oc1ccc(OCC(=O)OCC)c(C)c1)c1ccc(-c2cccc(C(F)(F)F)c2)nc1C

HCID67072103

未命名化合物

PRODUCTS

生成物

结构：CCCC(Oc1ccc(OCC(=O)O)c(C)c1)c1ccc(-c2cccc(C(F)(F)F)c2)nc1C

HCID21935838

未命名化合物

PROCEDURE

实验过程

A] The title compound was prepared in analogy to example 47, via [rac]-(2-methyl-4-{1-[2-methyl-6-(3-trifluoromethyl-phenyl)-pyridin-3-yl]-butoxy}-phenoxy)-acetic acid ethyl ester, but using in step A] [rac]-3-(1-chloro-butyl)-2-methyl-6-(3-trifluoromethyl-phenyl)-pyridine (example 4B]) instead of [rac]-3-(1-chloro-ethyl)-2-methyl-6-(3-trifluoromethyl-phenyl)-pyridine as light yellow oil.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b1f725efcfff4728922833dcb8d39183
来源数据集: uspto-grants-2006_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07115611B2
来源说明: uspto-grants-2006_10

反应 SMILES

C([O:3][C:4](=[O:36])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH:14]([C:18]2[C:19]([CH3:34])=[N:20][C:21]([C:24]3[CH:29]=[CH:28][CH:27]=[C:26]([C:30]([F:33])([F:32])[F:31])[CH:25]=3)=[CH:22][CH:23]=2)[CH2:15][CH2:16][CH3:17])=[CH:9][C:8]=1[CH3:35])C.ClC(C1C(C)=NC(C2C=CC=C(C(F)(F)F)C=2)=CC=1)CCC.ClC(C1C(C)=NC(C2C=CC=C(C(F)(F)F)C=2)=CC=1)C>>[CH3:35][C:8]1[CH:9]=[C:10]([O:13][CH:14]([C:18]2[C:19]([CH3:34])=[N:20][C:21]([C:24]3[CH:29]=[CH:28][CH:27]=[C:26]([C:30]([F:32])([F:31])[F:33])[CH:25]=3)=[CH:22][CH:23]=2)[CH2:15][CH2:16][CH3:17])[CH:11]=[CH:12][C:7]=1[O:6][CH2:5][C:4]([OH:36])=[O:3]