[Rac]-3-(1-chloro-propyl)-2-methyl-6-(4-trifluoromethyl-phenyl)-pyridine → [Rac]-(2-methyl-4-{1-[2-methyl-6-(4-trifluoromethyl-phenyl)-pyridin-3-yl]-propoxy}-phenoxy)-acetic acid
Reaction equation
C([O:3][C:4](=[O:35])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH:14]([C:17]2[C:18]([CH3:33])=[N:19][C:20]([C:23]3[CH:28]=[CH:27][C:26]([C:29]([F:32])([F:31])[F:30])=[CH:25][CH:24]=3)=[CH:21][CH:22]=2)[CH2:15][CH3:16])=[CH:9][C:8]=1[CH3:34])C.ClC(C1C(C)=NC(C2C=CC(C(F)(F)F)=CC=2)=CC=1)CC.ClC(C1C(C)=NC(C2C=CC=C(C(F)(F)F)C=2)=CC=1)CCC>>[CH3:34][C:8]1[CH:9]=[C:10]([O:13][CH:14]([C:17]2[C:18]([CH3:33])=[N:19][C:20]([C:23]3[CH:24]=[CH:25][C:26]([C:29]([F:31])([F:30])[F:32])=[CH:27][CH:28]=3)=[CH:21][CH:22]=2)[CH2:15][CH3:16])[CH:11]=[CH:12][C:7]=1[O:6][CH2:5][C:4]([OH:35])=[O:3]Participants
4
Reactant 3
Product 1
Procedure
A] The title compound was prepared in analogy to example 48, via [rac]-(2-methyl-4-{1-[2-methyl-6-(4-trifluoromethyl-phenyl)-pyridin-3-yl]-propoxy}-phenoxy)-acetic acid ethyl ester, but using in step A] [rac]-3-(1-chloro-propyl)-2-methyl-6-(4-trifluoromethyl-phenyl)-pyridine (example 36B]) instead of [rac]-3-(1-chloro-butyl)-2-methyl-6-(3-trifluoromethyl-phenyl)-pyridine as light yellow foam.
Sources & evidence
- ORD record
- ord-14e612c72797423e8ae16d951f6cf579
- Source dataset
- uspto-grants-2006_10
- Patent number
- US07115611B2
Reaction notes
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