[Rac]-3-(1-chloro-propyl)-2-methyl-6-(4-trifluoromethyl-phenyl)-pyridine → [Rac]-(2-methyl-4-{1-[2-methyl-6-(4-trifluoromethyl-phenyl)-pyridin-3-yl]-ethoxy}-phenoxy)-acetic acid
Reaction equation
C([O:3][C:4](=[O:34])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH:14]([C:16]2[C:17]([CH3:32])=[N:18][C:19]([C:22]3[CH:27]=[CH:26][C:25]([C:28]([F:31])([F:30])[F:29])=[CH:24][CH:23]=3)=[CH:20][CH:21]=2)[CH3:15])=[CH:9][C:8]=1[CH3:33])C.ClC(C1C(C)=NC(C2C=CC(C(F)(F)F)=CC=2)=CC=1)C.ClC(C1C(C)=NC(C2C=CC(C(F)(F)F)=CC=2)=CC=1)CC>>[CH3:33][C:8]1[CH:9]=[C:10]([O:13][CH:14]([C:16]2[C:17]([CH3:32])=[N:18][C:19]([C:22]3[CH:23]=[CH:24][C:25]([C:28]([F:31])([F:30])[F:29])=[CH:26][CH:27]=3)=[CH:20][CH:21]=2)[CH3:15])[CH:11]=[CH:12][C:7]=1[O:6][CH2:5][C:4]([OH:34])=[O:3]Participants
4
Reactant 3
Product 1
Procedure
A] The title compound was prepared in analogy to example 49, via [rac]-(2-methyl-4-{1-[2-methyl-6-(4-trifluoromethyl-phenyl)-pyridin-3-yl]-ethoxy}-phenoxy)-acetic acid ethyl ester, but using in step A] [rac]-3-(1-chloro-ethyl)-2-methyl-6-(4-trifluoromethyl-phenyl)-pyridine (example 17C]) instead of [rac]-3-(1-chloro-propyl)-2-methyl-6-(4-trifluoromethyl-phenyl)-pyridine as off-white foam.
Sources & evidence
- ORD record
- ord-7306439eeadc44099076ca396eef04ff
- Source dataset
- uspto-grants-2006_10
- Patent number
- US07115611B2
Reaction notes
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