HuagongsheHuagongshe Chemistry Print Report · For research reference only
(E)-3-(4-benzyloxy-2-methyl-phenyl)-acrylic acid ethyl ester → Ethyl 3-(4-hydroxy-2-methylphenyl)propanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (E)-3-(4-benzyloxy-2-methyl-phenyl)-acrylic acid ethyl ester | HCID 21986386 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Ethyl 3-(4-hydroxy-2-methylphenyl)propanoate | HCID 21986481 | 100% |
Reaction Steps
5 g (16.8 mmol) of the above prepared (E)-3-(4-benzyloxy-2-methyl-phenyl)-acrylic acid ethyl ester was dissolved in 50 ml of tetrahydrofuran and hydrogenated over 0.8 g of 10% of palladium on charcoal as catalyst at ambient temperature and atmospheric pressure. Filtering off the catalyst and evaporating the solvent yielded 3.5 g of the title compound as light yellow oil (100% of theory).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07115611B2 |
| Source dataset | uspto-grants-2006_10 |
| ORD ID | ord-cec737d87c654c609e59bcc912643ce3 |
| Source note | uspto-grants-2006_10 |