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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1242389Generated: October 26, 2026

(E)-3-(4-benzyloxy-2-methyl-phenyl)-acrylic acid ethyl ester → Ethyl 3-(4-hydroxy-2-methylphenyl)propanoate

https://huagongshe.com/reaction/1242389

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(E)-3-(4-benzyloxy-2-methyl-phenyl)-acrylic acid ethyl esterHCID 21986386—
CatalystPalladiumHCID 23938—
SolventTetrahydrofuranHCID 8028—
ProductEthyl 3-(4-hydroxy-2-methylphenyl)propanoateHCID 21986481100%

Reaction Steps

5 g (16.8 mmol) of the above prepared (E)-3-(4-benzyloxy-2-methyl-phenyl)-acrylic acid ethyl ester was dissolved in 50 ml of tetrahydrofuran and hydrogenated over 0.8 g of 10% of palladium on charcoal as catalyst at ambient temperature and atmospheric pressure. Filtering off the catalyst and evaporating the solvent yielded 3.5 g of the title compound as light yellow oil (100% of theory).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07115611B2
Source datasetuspto-grants-2006_10
ORD IDord-cec737d87c654c609e59bcc912643ce3
Source noteuspto-grants-2006_10