反应详情

1-phenyl-5-methyl-2-pyridinone (555.7 mg, 3 mmol) was reacted with Lawesson's reagent (606.7 mg, 1.5 mmol) in toluene (5 ml) at 90° C. Reaction mixture was evaporated and the target compound was isolated by column chromatography (20-30% ethyl acetate-hexane) followed by crystallization from methyl-tert-butyl ether. Yield 403 mg (67%), yellow solid. The 1H NMR spectra was consistent with the structure of Compound 18.

1. customReaction mixture
2. customwas evaporated
3. customthe target compound was isolated by column chromatography (20-30% ethyl acetate-hexane)
4. customfollowed by crystallization from methyl-tert-butyl ether