Carbon Dioxide → HCID 21935657, compound

Participants

Reaction Conditions

Reaction Steps

Within 20 min was dropped 50 ml (60 mmol) of DIBALH (1.2 M solution in toluene) to a dry ice cooled (−30° C.) solution of 6.83 g (20 mmol) 4-(2-methoxy-ethyl)-2-(6-trifluoromethyl-pyridin-3-yl)-pyrimidine-5-carboxylic acid methyl ester and 4-(2-methoxy-ethyl)-2-(6-trifluoromethyl-pyridin-3-yl)-pyrimidine-5-carboxylic acid ethyl ester in 100 ml of THF. The reaction was warmed up (0° C. for 1 h) and stirred 1 h at RT. The reaction was cooled (0° C.) and neutralized with KHSO4 solution (10%). The mixture was extracted with ether (3×), the organic phase was washed with a NaCl solution (10%), dried (Na2SO4) and evaporated. The crude product was crystallized (dichloromethane/ether, 0° C.) to give 6.72 g of pure [4-(2-methoxy-ethyl)-2-(6-trifluoromethyl-pyridin-3-yl)-pyrimidin-5-yl]-methanol.

Provenance & Evidence