Lithium Hydroxide → HCID 21935807, compound

Participants

Reaction Steps

A solution of 133 mg (0.25 mmol) 2-{4-[4-(2-methoxy-ethyl)-2-(6-trifluoromethyl-pyridin-3-yl)-pyrimidin-5-ylmethoxy]-2-methyl-phenoxy}-2-methyl-propionic acid ethyl ester (example 101A]) in 1.5 ml of THF/MeOH (1:1) was cooled (0° C.) treated with 0.75 ml 1N LiOH and stirred for 15 h at RT. The reaction mixture was taken up in ether and washed with aqueous 10% KHSO4 solution and aqueous 10% NaCl. The organic phase was dried (Na2SO4) and evaporated. The crude product was suspended in ether (RT to 4° C.) and filtered to give 66 mg of the title compound as a white powder of mp. 140.5–141.5° C., dec.

Provenance & Evidence