Thionyl Chloride → 5-Chloromethyl-4-trifluoromethyl-2-(4-trifluoromethyl-phenyl)-pyrimidine

Participants

Reaction Steps

A cooled (0° C.) solution of 0.081 g (0.25 mmol) of [4-trifluoromethyl-2-(4-trifluoromethyl-phenyl)-pyrimidin-5-yl]-methanol in 2.5 ml dichloromethane was treated with 0.04 ml (0.50 mmol) thionylchloride and stirred for 14 h at RT. The reaction was evaporated, dissolved in ether and twice in heptane and evaporated to give 0.077 g of pure 5-chloromethyl-4-trifluoromethyl-2-(4-trifluoromethyl-phenyl)-pyrimidine.

Provenance & Evidence