Ethyl 2-(4-hydroxy-2-methylphenoxy)-2-methylpropanoate → HCID 86597810, compound

HRID 1242442Notes

Reaction equation

HRID 1242442 reaction equation
[CH2:1]([O:3][C:4](=[O:17])[C:5]([O:8][C:9]1[CH:14]=[CH:13][C:12]([OH:15])=[CH:11][C:10]=1[CH3:16])([CH3:7])[CH3:6])[CH3:2].Cl[CH2:19][C:20]1[C:21]([C:36]([F:39])([F:38])[F:37])=[CH:22][C:23]([C:26]2[CH:31]=[CH:30][C:29]([C:32]([F:35])([F:34])[F:33])=[CH:28][CH:27]=2)=[N:24][CH:25]=1>>[CH2:1]([O:3][C:4](=[O:17])[C:5]([CH3:6])([O:8][C:9]1[CH:14]=[CH:13][C:12]([O:15][CH2:19][C:20]2[CH:25]=[N:24][C:23]([C:26]3[CH:31]=[CH:30][C:29]([C:32]([F:34])([F:33])[F:35])=[CH:28][CH:27]=3)=[CH:22][C:21]=2[C:36]([F:37])([F:39])[F:38])=[CH:11][C:10]=1[CH3:16])[CH3:7])[CH3:2]

Participants

3

Reactant 2

HCID 16756990Ethyl 2-(4-hydroxy-2-methylphenoxy)-2-methylpropanoateHCID 21935643HCID 21935643, compound

Product 1

HCID 86597810HCID 86597810, compound

Procedure

In analogy to the procedures described in example 101A], 2-(4-hydroxy-2-methyl-phenoxy)-2-methyl-propionic acid ethyl ester (described in WO 02/092590) was reacted with 5-chloromethyl-4-trifluoromethyl-2-(4-trifluoromethyl-phenyl)-pyridine (example 108D]) to give 2-methyl-2-{2-methyl-4-[4-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyridin-3-ylmethoxy]-phenoxy}-propionic acid ethyl ester, which was subsequently saponified in analogy to the procedure described in example 101] to yield the title compound as off-white crystalls of mp. 148–149° C.

Sources & evidence

ORD record
ord-9286b4d38c7641b48fff7a29c92ab756
Source dataset
uspto-grants-2006_10
Patent number
US07115611B2

Reaction notes

Loading…