Boron tribromide → HCID 21935908, compound

HRID 1242444Notes

Reaction equation

HRID 1242444 reaction equation
[Cl:1][CH2:2][C:3]1[C:4]([CH2:19][CH2:20][O:21]C)=[N:5][C:6]([C:9]2[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=2)=[N:7][CH:8]=1.B(Br)(Br)Br>>[Cl:1][CH2:2][C:3]1[C:4]([CH2:19][CH2:20][OH:21])=[N:5][C:6]([C:9]2[CH:10]=[CH:11][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:13][CH:14]=2)=[N:7][CH:8]=1

Participants

3

Reactant 2

HCID 25134Boron tribromideHCID 219356255-Chloromethyl-4-(2-methoxy-ethyl)-2-(4-trifluoromethyl-phenyl)-pyrimidine

Product 1

HCID 21935908HCID 21935908, compound

Procedure

In analogy to the procedures described in examples 103A], 5-chloromethyl-4-(2-methoxy-ethyl)-2-(4-trifluoromethyl-phenyl)-pyrimidine and BBr3 (1M in dichloromethane) gave the title compound as a yellow oil, which was used without further purification. MS: 317.1 (M+H, Cl)+.

Sources & evidence

ORD record
ord-4c930405158d4deaa92d74a50d43dc82
Source dataset
uspto-grants-2006_10
Patent number
US07115611B2

Reaction notes

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