Ethyl 2-(4-hydroxy-2-methylphenoxy)-2-methylpropanoate → HCID 86597811, compound

HRID 1242445Notes

Reaction equation

HRID 1242445 reaction equation
[CH2:1]([O:3][C:4](=[O:17])[C:5]([O:8][C:9]1[CH:14]=[CH:13][C:12]([OH:15])=[CH:11][C:10]=1[CH3:16])([CH3:7])[CH3:6])[CH3:2].[F:18][C:19]([F:43])([F:42])[O:20][C:21]1[CH:26]=[CH:25][C:24]([C:27]2[N:32]=[C:31]([C:33]([F:36])([F:35])[F:34])[C:30]([CH2:37]OS(Cl)=O)=[CH:29][N:28]=2)=[CH:23][CH:22]=1>>[CH2:1]([O:3][C:4](=[O:17])[C:5]([CH3:6])([O:8][C:9]1[CH:14]=[CH:13][C:12]([O:15][CH2:37][C:30]2[C:31]([C:33]([F:36])([F:34])[F:35])=[N:32][C:27]([C:24]3[CH:25]=[CH:26][C:21]([O:20][C:19]([F:42])([F:43])[F:18])=[CH:22][CH:23]=3)=[N:28][CH:29]=2)=[CH:11][C:10]=1[CH3:16])[CH3:7])[CH3:2]

Participants

3

Reactant 2

HCID 16756990Ethyl 2-(4-hydroxy-2-methylphenoxy)-2-methylpropanoateHCID 86597812HCID 86597812, compound

Product 1

HCID 86597811HCID 86597811, compound

Procedure

In analogy to the procedures described in example 101A], 2-(4-hydroxy-2-methyl-phenoxy)-2-methyl-propionic acid ethyl ester (described in WO 02/092590) was reacted with chlorosulfurous acid 2-(4-trifluoromethoxy-phenyl)-4-trifluoromethyl-pyrimidin-5-ylmethyl ester (example 111F]) to give 2-methyl-2-{2-methyl-4-[2-(4-trifluoromethoxy-phenyl)-4-trifluoromethyl-pyrimidin-5-ylmethoxy]-phenoxy}-propionic acid ethyl ester, which was subsequently saponified in analogy to the procedure described in example 101B] to yield the title compound as a white powder of mp. 153.5–154.5° C.

Sources & evidence

ORD record
ord-8e5d33a474804a5697e0e2d7bbe1d8c8
Source dataset
uspto-grants-2006_10
Patent number
US07115611B2

Reaction notes

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