Diisobutylaluminum hydride → HCID 21935738, compound

Participants

Reaction Steps

0.45 g (1.21 mmol) 2-(4-Trifluoromethoxy-phenyl)-4-trifluoromethyl-pyrimidine-5-carbonyl chloride in 4 ml tetrahydrofurane were cooled (-30° C.) and treated during 10 min with 2.23 ml (2.20 mmol) of a DIBALH-solution (1.2 M in toluene). The solution was allowed to come to 0° C. (1.5 h). The reaction was then powered to an ice-cooled aqueous 10% KHSO4 solution and extracted with ether. The ether-phase was washed with aqueous 10% NaCl solution, dried (NaSO4) and evaporated. The crude product was purified by flash chromatography over silica gel with heptane/AcOEt 9:1, to give 0.29 g of the title compound as an off-white solid.

Provenance & Evidence