Thionyl Chloride → HCID 86597812, compound

Participants

Reaction Steps

A cooled (0° C.) solution of 0.40 g (1.20 mmol) of [2-(4-trifluoromethoxy-phenyl)-4-trifluoromethyl-pyrimidin-5-yl]-methanol in 12 ml dichloromethane was treated with 0.10 ml (1.32 mmol) thionylchloride and stirred for 30 min at RT. The reaction was cooled (0° C.), treated with 0.08 ml (1.08 mmol) thionylchloride and stirred for 30 min at RT. The solution was evaporated, dissolved in ether and twice in heptane and evaporated to give 0.44 g of the title compound as an off-white powder.

Provenance & Evidence