Trifluoroacetic acid → HCID 21935915, compound

Participants

Reaction Conditions

Reaction Steps

0.23 g (0.42 mmol) of 2-methyl-2-[4-({[2-methyl-6-(4-trifluoromethyl-phenyl)-pyridin-3-ylmethyl]-carbamoyl}-methyl)-phenoxy]-propionic acid tert-butyl ester was dissolved in 10 ml of MeCl2. Then, 0.14 ml=0.139 g (1.28 mmol) of anisole was added followed by 0.32 ml=0.48 g (4.2 mmol) of trifluoroacetic acid. The reaction mixture was stirred at reflux (oil bath 50° C.) for 16 hours. It was then poured into crashed ice and extracted twice with MeCl2. The combined organic phases were washed with water, dried over anhydrous magnesium sulfate and evaporated. The crude product was purified by flash chromatography (SiO2, MeCl2/MeOH) to give 0.17 g of the title compound as colorless solid.

Provenance & Evidence