Sodium Iodide → HCID 67072101, compound

Participants

Reaction Steps

In analogy to the procedure described in example 101A], 2-(4-hydroxy-2-methyl-phenoxy)-2-methyl-propionic acid ethyl ester (described in WO 02/092590) was reacted with 5-chloromethyl-4-(2-methoxy-ethyl)-2-(4-trifluoromethyl-phenyl)-pyrimidine (example 110B]) in the presence of catalytic amount of sodium iodide to give 2-{4-[4-(2-methoxy-ethyl)-2-(4-trifluoromethyl-phenyl)-pyrimidin-5-ylmethoxy]-2-methyl-phenoxy}-2-methyl-propionic acid ethyl ester, which was subsequently saponified in analogy to the procedure described in example 102] to yield the title compound as white crystals of mp. 119.5–120.0° C.

Provenance & Evidence