Thionyl Chloride → HCID 21935634, compound

HRID 1242513Notes

Reaction equation

[CH3:1][O:2][CH2:3][C:4]1[C:9]([CH2:10]O)=[C:8]([CH3:12])[N:7]=[C:6]([C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([C:19]([F:22])([F:21])[F:20])[CH:14]=2)[N:5]=1.S(Cl)([Cl:25])=O>>[Cl:25][CH2:10][C:9]1[C:4]([CH2:3][O:2][CH3:1])=[N:5][C:6]([C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([C:19]([F:22])([F:21])[F:20])[CH:14]=2)=[N:7][C:8]=1[CH3:12]

Participants

Reactant 2

HCID 24386Thionyl Chloride

HCID 21935919HCID 21935919, compound

Product 1

HCID 21935634HCID 21935634, compound

Procedure

In analogy to the procedure described in example 113H], [4-methoxymethyl-6-methyl-2-(3-trifluoromethyl-phenyl)-pyrimidin-5-yl]-methanol and thionylchloride gave the title compound as a brown viscous oil.

Sources & evidence

ORD record: ord-f20a1a6cd0394cee85268226d59c387d
Source dataset: uspto-grants-2006_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07115611B2

Reaction notes

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