HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 5-Chloromethyl-4-cyclopropyl-2-(4-trifluoromethoxy-phenyl)-pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | [4-Cyclopropyl-2-(4-trifluoromethoxy-phenyl)-pyrimidin-5-yl]-methanol | HCID 21935760 | — |
| Product | 5-Chloromethyl-4-cyclopropyl-2-(4-trifluoromethoxy-phenyl)-pyrimidine | HCID 21935645 | — |
Reaction Steps
In analogy to the procedure described in example 113H], [4-cyclopropyl-2-(4-trifluoromethoxy-phenyl)-pyrimidin-5-yl]-methanol and thionylchloride gave the title compound as a light brown solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07115611B2 |
| Source dataset | uspto-grants-2006_10 |
| ORD ID | ord-74f12c75273f40458dd12beff4386d90 |
| Source note | uspto-grants-2006_10 |