Sodium → 3-Amino-4-cyclopropyl-but-2-enoic acid ethyl ester

Participants

Reaction Steps

397 mg (2 mmol) 5-(1-Amino-2-cyclopropyl-ethylidene)-2,2-dimethyl-[1,3]dioxane-4,6-dione were added to a solution of 45 mg (2 mmol) sodium in 3 ml ethanol. The reaction mixture was heated under reflux for 14 h, diluted with dichloromethane and poured onto ice water/brine 1/1. The organic layer was dried over sodium sulfate and the solvent removed under reduced pressure to give 231 mg (1.4 mmol, 77%) of the title compound as orange oil.

Provenance & Evidence