N,N,N',N'-Tetramethylazodicarboxamide → 2-{4-[2-Cyclopropylmethyl-6-(4-trifluoromethoxy-phenyl)-4-trifluoromethyl-pyridin-3-ylmethoxy]-2-methyl-phenoxy}-2-methyl-propionic acid ethyl ester

Participants

Role	Name	HCID	Charge
Reactant	N,N,N',N'-Tetramethylazodicarboxamide	HCID 4278	—
Reactant	Tributylphosphine	HCID 13831	—
Reactant	Ethyl 2-(4-hydroxy-2-methylphenoxy)-2-methylpropanoate	HCID 16756990	—
Reactant	[2-Cyclopropylmethyl-6-(4-trifluoromethoxy-phenyl)-4-trifluoromethyl-pyridin-3-yl]-methanol	HCID 21935688	—
Product	2-{4-[2-Cyclopropylmethyl-6-(4-trifluoromethoxy-phenyl)-4-trifluoromethyl-pyridin-3-ylmethoxy]-2-methyl-phenoxy}-2-methyl-propionic acid ethyl ester	HCID 86597823	—

Reaction Steps

In analogy to the procedure described in example 43E], 2-(4-hydroxy-2-methyl-phenoxy)-2-methyl-propionic acid ethyl ester (described in WO 02/092590) was reacted with [2-cyclopropylmethyl-6-(4-trifluoromethoxy-phenyl)-4-trifluoromethyl-pyridin-3-yl]-methanol in the presence of N,N,N′,N′-tetramethylazodicarboxamide and tributylphosphine to give the title compound as colorless crystals.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07115611B2
Source dataset	uspto-grants-2006_10
ORD ID	ord-56f3824fcb024547bb7297ddf5368ebc
Source note	uspto-grants-2006_10