HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Amino-3-cyclopropyl-acrylic acid ethyl ester → 2-Cyclopropyl-6-(4-trifluoromethoxy-phenyl)-4-trifluoromethyl-nicotinic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Amino-3-cyclopropyl-acrylic acid ethyl ester | HCID 53401889 | — |
| Reactant | HCID 178520888 | HCID 178520888 | — |
| Product | 2-Cyclopropyl-6-(4-trifluoromethoxy-phenyl)-4-trifluoromethyl-nicotinic acid ethyl ester | HCID 86597789 | — |
Reaction Steps
In analogy to the procedure described in example 152E], 3-amino-3-cyclopropyl-acrylic acid ethyl ester (J. P. Célérier, E. Deloisy, P. Kapron, G. Lhommet, P. Maitte, Synthesis 1981, 130–133) was reacted with (Z)-4,4,4-trifluoro-3-hydroxy-1-(4-trifluoromethoxy-phenyl)-but-2-en-1-one (example 152D]) to give the title compound as colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07115611B2 |
| Source dataset | uspto-grants-2006_10 |
| ORD ID | ord-f874994ee09545c9bce32ca86a3d2481 |
| Source note | uspto-grants-2006_10 |