Aluminium lithium hydride → HCID 21935734, compound

HRID 1242532Notes

Reaction equation

HRID 1242532 reaction equation
C([O:3][C:4](=O)[C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:16]=[CH:15][C:14]([O:17][C:18]([F:21])([F:20])[F:19])=[CH:13][CH:12]=2)=[N:7][C:6]=1[C:22]([F:25])([F:24])[F:23])C.[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[F:21][C:18]([F:19])([F:20])[O:17][C:14]1[CH:15]=[CH:16][C:11]([C:8]2[N:7]=[C:6]([C:22]([F:23])([F:24])[F:25])[C:5]([CH2:4][OH:3])=[CH:10][CH:9]=2)=[CH:12][CH:13]=1

Participants

3

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 86597787HCID 86597787, compound

Product 1

HCID 21935734HCID 21935734, compound

Procedure

In analogy to the procedure described in example 43D], 6-(4-trifluoromethoxy-phenyl)-2-trifluoromethyl-nicotinic acid ethyl ester was treated with lithium aluminium hydride to give the title compound as colorless crystals.

Sources & evidence

ORD record
ord-d57391ebd5c54130930a953fc1e9fbbc
Source dataset
uspto-grants-2006_10
Patent number
US07115611B2

Reaction notes

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