O-((4-Methoxyphenyl)methyl)hydroxylamine → HCID 58714542, compound

HRID 1242544Notes

Reaction equation

HRID 1242544 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:12][C:11](=O)[CH2:10][C@H:9]1[C:14]([OH:16])=[O:15])=[O:7])([CH3:4])([CH3:3])[CH3:2].[NH2:17][O:18][CH2:19][C:20]1[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[CH:22][CH:21]=1>>[C:1]([O:5][C:6]([N:8]1[CH2:12][C:11](=[N:17][O:18][CH2:19][C:20]2[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[CH:22][CH:21]=2)[CH2:10][C@H:9]1[C:14]([OH:16])=[O:15])=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 120426O-((4-Methoxyphenyl)methyl)hydroxylamine2×HCID 11593804(2S)-1-(tert-butoxycarbonyl)-4-oxopyrrolidine-2-carboxylic acid2×

Product 1

HCID 58714542HCID 58714542, compoundYield 85%

Procedure

The same method as employed in the preparation of Intermediate 2, but starting from (2S)-1-(tert-butoxycarbonyl)-4-oxo-2-pyrrolidinecarboxylic acid (Intermediate 1) and 1-[(aminooxy)methyl]-4-methoxybenzene (intermediate 6), gave the title compound as a gum in a 85% yield.

Sources & evidence

ORD record
ord-56108e77c3eb43749b32fc3b3ec104bb
Source dataset
uspto-grants-2006_10
Patent number
US07115639B2

Reaction notes

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